Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation
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منابع مشابه
Intramyocardial delivery of basic fibroblast growth factor-impregnated gelatin hydrogel microspheres enhances collateral circulation to infarcted canine myocardium.
The present study examined whether basic fibroblast growth factor (bFGF)-impregnated acidic gelatin hydrogel microspheres (AGHM) would enhance collateral development to the infarct area in dogs with coronary occlusion. Studies were conducted in 28 dogs with a 2-week occlusion of the proximal left anterior descending coronary artery (LAD). The dogs were divided into 3 groups according to treatme...
متن کاملGelatin sheet incorporating basic fibroblast growth factor enhances healing of devascularized sternum in diabetic rats.
BACKGROUND Poor healing of the sternum often limits the use of bilateral internal thoracic arteries (BITAs) after coronary bypass surgery in diabetic patients. We have reported that a gelatin sheet that incorporates basic fibroblast growth factor (bFGF) accelerates sternal healing after BITA removal in normal rats. This study evaluated the effects of the above method for sternal healing in diab...
متن کاملFactor for the Development of Functional Collateral Vessels Gelatin Hydrogel Microspheres Enable Pinpoint Delivery of Basic Fibroblast Growth
Akihiro Hosaka, Hiroyuki Koyama, Toshihiro Kushibiki, Yasuhiko Tabata, Nobuhiro Factor for the Development of Functional Collateral Vessels Gelatin Hydrogel Microspheres Enable Pinpoint Delivery of Basic Fibroblast Growth Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2004 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Green...
متن کاملGelatin hydrogel microspheres enable pinpoint delivery of basic fibroblast growth factor for the development of functional collateral vessels.
BACKGROUND Various growth factors promote collateral vessel development and are regarded as promising for the treatment of vascular occlusive diseases. However, an efficacious delivery system for them has yet to be established. We devised a strategy to augment functional collateral vessels by using acidic gelatin hydrogel microspheres (AGHMs) incorporating basic fibroblast growth factor (bFGF)....
متن کاملEnhanced intestinal anastomotic healing with gelatin hydrogel incorporating basic fibroblast growth factor.
Anastomotic leakage is a common complication of intestinal surgery. In an attempt to resolve this issue, a promising approach is enhancement of anastomotic wound healing. A method for controlled release of basic fibroblast growth factor (bFGF) using a gelatin hydrogel was developed with the objective of investigating the effects of this technology on intestinal anastomotic healing. The small in...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2002
ISSN: 0022-5223
DOI: 10.1067/mtc.2002.121293